DisProt Protein Disorder Annotations

DisProt is a manually curated database of intrinsically disordered proteins and regions, including experimental evidence and functional annotations for protein disorder.

Splits

The split is deterministic by DisProt ID: sha256(disprot_id) % 10. Bucket 0 is test; buckets 1 through 9 are train.

Split	Rows
train	2,875
test	324
total	3,199

Dataset Statistics

Field	Value
Protein entries	3,199
Curated region rows	13,396

Usage

pip install datasets

Load all splits:

from datasets import load_dataset

ds = load_dataset("LiteFold/DisProt")
print(ds)
print(ds["train"][0]["disprot_id"])

Load one split:

from datasets import load_dataset

train = load_dataset("LiteFold/DisProt", split="train")

Filter proteins with high disorder content:

from datasets import load_dataset

ds = load_dataset("LiteFold/DisProt", split="train")
high_disorder = ds.filter(lambda row: row["disorder_content"] is not None and row["disorder_content"] >= 0.5)
print(high_disorder[0])

Load the region-level metadata:

import pandas as pd
from huggingface_hub import hf_hub_download

path = hf_hub_download(
    repo_id="LiteFold/DisProt",
    repo_type="dataset",
    filename="metadata/regions.parquet",
)
regions = pd.read_parquet(path)
print(regions.head())

Key Columns

Column	Description
disprot_id	DisProt protein identifier.
accession	UniProt accession.
name	Protein name.
organism	Organism name.
ncbi_taxon_id	NCBI taxonomy ID.
length	Protein sequence length.
disorder_content	Fraction of sequence annotated as disordered.
dataset_labels	DisProt dataset labels.
sequence	Protein sequence.
region_count	Number of curated region annotations.
region_ids	Curated region IDs.
region_starts	Region start positions.
region_ends	Region end positions.
region_terms	Region term names.
evidence_codes	Region evidence codes.
reference_ids	Region reference IDs.
cross_refs	Region cross-references such as PDB IDs.
feature_databases	Feature sources such as Pfam or Gene3D.
feature_ids	Feature IDs.
gene_names	Gene names and synonyms.
split_bucket	Deterministic split bucket from sha256(disprot_id) % 10.

Citation

@article{quaglia2022disprot,
  title   = {{DisProt} in 2022: improved quality and accessibility of protein intrinsic disorder annotation},
  author  = {Quaglia, Federica and M{\'e}sz{\'a}ros, B{\'a}lint and Salladini, Elisa and others},
  journal = {Nucleic Acids Research},
  volume  = {50},
  number  = {D1},
  pages   = {D480--D487},
  year    = {2022},
  doi     = {10.1093/nar/gkab1082}
}